Bisoprolol shortage — US supply status & alternatives

Bisoprolol

ATC C07AB07 · Selective beta-1 blocker

🇦🇺 AUST R 377970 · Cipla Australia Pty Ltd

In supply · Australia

WHO Essential Medicine

ConcorZebetaCardicorBisoprolol Stada

In supply · 🇦🇺 Australia · short in🇺🇸 US🇨🇦 CA🇪🇸 ES🇧🇪 BE🇮🇪 IE

In supply in Australia

Reading today’s signals…

🇦🇺 AUAEMPA$4.00DPMQ A$22.84details →

✓ Can I substitute?

Per normal rules

Confirm with prescriber

Product attributes reference data we hold

Active ingredient (INN)	Bisoprolol
Brand names	Concor, Zebeta, Cardicor, Bisoprolol Stada
ATC level 5	C07AB07
ATC level 4	C07AB
Drug class	Selective beta-1 blocker
Therapeutic category	Cardiovascular
Strength	1.25mg · 2.5mg · 5mg · 10mg
Dosage form	tablet
Route of administration	oral
WHO Essential Medicine	Yes (2023)
Controlled substance	No
Marketing-authorisation holders	Cipla Australia Pty Ltd, Alphapharm Pty Ltd, TEVA UK LIMITED, ROSEMONT PHARMACEUTICALS LIMITED +4 more
Registrations on file	25
Patient information leaflet (PIL)	Not on file
Summary of product characteristics (SPC)	Not on file

Trade price 🇦🇺 PBS · July 2026

🇦🇺 AU

● Official price on file

Ex-manufacturer

A$4.00

AEMP

Dispensed (DPMQ)

A$22.84

incl. fees

Pack

bisoprolol fumarate 2.5 mg tablet, 28

tablet

Source: PBSEffective July 2026 · AUD

Other markets

🇬🇧 GB

£0.68

Drug Tariff

🇺🇸 US

US$0.21

Acquisition

🇪🇸 ES

€2.50

Retail price

🇫🇷 FR

€5.27

Retail price

Global API supply base 🇺🇸 FDA Drug Master Files · active Type II

13 API manufacturers

Manufacturers with an active Type II Drug Master File — i.e. cleared to supply this active ingredient into the US market. A proxy for how concentrated the global manufacturing base is.

Low concentration risk

Micro Labs LTDArevipharma GMBHMerck KgaaCorden Pharma ChenoveMoehs Iberica SlUnichem Laboratories LTD+7 more

Manufacturing countries: India, Germany, France, Spain, Taiwan · Source: FDA List of Drug Master Files

Shortage status by regulator official notices

🇺🇸

United States

FDA MedWatch · 2mo ago

High

🇨🇦

Canada

HC · 3h ago

Medium

🇧🇪

FAMHP · 1mo ago

Medium

🇪🇸

Spain

AEMPS · 2mo ago

Medium

🇮🇪

Ireland

HPRA · 3mo ago

Medium

🇦🇺

Australia

TGA · 2mo ago

Resolved

Sources official regulators

🇨🇦

verified 3h ago

verify ↗

🇧🇪

FAMHP

verified 1mo ago

verify ↗

🇦🇺

TGA

verified 2mo ago

verify ↗

🇪🇸

AEMPS

verified 2mo ago

verify ↗

🇺🇸

FDA MedWatch

verified 2mo ago

verify ↗

🇮🇪

HPRA

verified 3mo ago

verify ↗

Registration recordmarketing-authorisation holders

Registrations & marketing-authorisation holders25 registrations · 8 MA holders

Product	Strength	Form	Market	MA holder	Status
Cipla Bisoprolol	2.5 mg	—	🇦🇺 AU	Cipla Australia Pty Ltd	Active
BISPRO bisoprolol fumarate1	1.25 mg	—	🇦🇺 AU	Alphapharm Pty Ltd	Active
BISPRO bisoprolol fumarate	2.5 mg	—	🇦🇺 AU	Alphapharm Pty Ltd	Active
BISPRO bisoprolol fumarate	3.75 mg	—	🇦🇺 AU	Alphapharm Pty Ltd	Active
BISPRO bisoprolol fumarate	5 mg	—	🇦🇺 AU	Alphapharm Pty Ltd	Active
BISPRO bisoprolol fumarate	7.5 mg	—	🇦🇺 AU	Alphapharm Pty Ltd	Active
BISPRO bisoprolol fumarate10 mg tablet blister pack	10 mg	—	🇦🇺 AU	Alphapharm Pty Ltd	Active
Cipla Bisoprolol	5 mg	—	🇦🇺 AU	Cipla Australia Pty Ltd	Active
Cipla Bisoprolol	10 mg	—	🇦🇺 AU	Cipla Australia Pty Ltd	Active
Bisoprolol Fumarate	1.25 MG	tablet	🇬🇧 GB	TEVA UK LIMITED	Active
Bisoprolol Fumarate	2.5 MG	tablet	🇬🇧 GB	TEVA UK LIMITED	Active
Bisoprolol Fumarate	1MG	solution	🇬🇧 GB	ROSEMONT PHARMACEUTICALS LIMITED	Active
Bisoprolol Fumarate	3.75 MG	tablet	🇬🇧 GB	SANDOZ LIMITED	Active
Bisoprolol Fumarate	5 MG	tablet	🇬🇧 GB	SANDOZ LIMITED	Active
Bisoprolol Fumarate	7.5 MG	tablet	🇬🇧 GB	SANDOZ LIMITED	Active

+10 more registrations on file

For health-professional reference only. Mederti aggregates shortage and substitution information from official regulatory sources. It is not clinical advice and data may be incomplete or delayed. Confirm any substitution or supply decision against the primary regulator source, the prescriber, and current clinical references (e.g. AMH) before acting. Terms.